(1S,2S,3R,5S)-(+)-2,3-Pinanediol CAS 18680-27-8 e.e ≥99.0% Purity ≥99.0% Bortezomib Intermediate High Purity

Short Description:

Chemical Name: (1S,2S,3R,5S)-(+)-2,3-Pinanediol

CAS: 18680-27-8

Appearance: White to Off-White Crystallized Powder

e.e: ≥99.0% Purity: ≥99.0% (GC)

Intermediate of Bortezomib (CAS 179324-69-7) in the treatment of Multiple Myeloma

Chiral Compounds, Commercial Production

E-mail: alvin@ruifuchem.com


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Description:

Chemical Properties:

Chemical Name (1S,2S,3R,5S)-(+)-2,3-Pinanediol
Synonyms (1S,2S,3R,5S)-2,6,6-Trimethylbicyclo[3.1.1]heptane-2,3-diol
CAS Number 18680-27-8
CAT Number RF-CC290
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C10H18O2
Molecular Weight 170.25
Solubility Chloroform, Toluene 
Shipping Condition Shipped Under Ambient Temperature
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White to Off-White Crystallized Powder
Melting Point 56.0~59.0℃
Loss on Drying ≤0.50%
Residue on Ignition ≤0.50%
Enantiomeric Excess e.e≥99.0% 
Purity / Analysis Method ≥99.0% (GC)
Specific Rotation [α]20/D +8.5° to +9.5° (C=6.5, Toluene)
Infrared Spectrum Conforms
Test Standard Enterprise Standard
Usage Chiral Compounds; Pharmaceutical Intermediates; Bortezomib Intermediate

Package & Storage:

Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS 18680-27-8) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and fine chemical synthesis.
Shanghai Ruifu Chemical Co., Ltd. plays an important role in the chiral chemistry, the company is committed to the production of chiral compounds. Our products are widely praised by customers.  

(1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS 18680-27-8), is a useful Chiral reagent used in the synthesis of homochiral α-hydroxyketones and in the resolution of prolineboronate esters. It is also a useful precursor to a chiral allyl boronate used in a preparation of chiral β-hydroxyallylsilanes.

(1S,2S,3R,5S)-(+)-2,3-Pinanediol (CAS 18680-27-8) is an Intermediate of Bortezomib (CAS 179324-69-7) in the treatment of Multiple Myeloma. Bortezomib, a potent ubiquitin proteasome (26S) inhibitor (Ki=0.6 nM), was launched in the US as a treatment for multiple myeloma. This proteasome is required for the proteolytic degradation of the majority of cellular proteins and is present in all cells. It is required for the control of inflammatory processes, cell cycle regulation and gene expression and is a novel target in cancer treatment. 

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